The use of lemon balm has been documented in 300 BCE, which means that this herb has been in use for well over two millennia. Historians believe lemon balm to have originated in Southern Europe and was introduced to Spain in the 7th century by Moors.
The Greeks referred to it by what is now its genus name—Melissa. Melissa is the Greek word for bee. The Greek physician Dioscorides, who lived in the first century wrote that lemon balm aided with menstruation and gout. Pliny the Elder stated that lemon balm encouraged bees to return to their hives when planted in the vicinity of the hives. It would be cultivated all over Europe by the Middle Ages. The Persian philosopher Avicenna (who lived from the year 980 to 1037) wrote that lemon balm was an effective treatment for depression.